Precision medicine advances in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous, unpredictable and ultimately
lethal chronic lung disease. Over the last decade, two anti-fibrotic agents have been shown …
lethal chronic lung disease. Over the last decade, two anti-fibrotic agents have been shown …
Idiopathic pulmonary fibrosis
Idiopathic Pulmonary Fibrosis | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells
Loss of alveolar type 2 cells (AEC2s) and the ectopic appearance of basal cells in the alveoli
characterize severe lung injuries such as idiopathic pulmonary fibrosis (IPF). Here we …
characterize severe lung injuries such as idiopathic pulmonary fibrosis (IPF). Here we …
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …
A proteomic atlas of senescence-associated secretomes for aging biomarker development
The senescence-associated secretory phenotype (SASP) has recently emerged as a driver
of and promising therapeutic target for multiple age-related conditions, ranging from …
of and promising therapeutic target for multiple age-related conditions, ranging from …
Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study
Background Cellular senescence is a key mechanism that drives age-related diseases, but
has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a …
has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a …
Idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by
progressive lung scarring and the histological picture of usual interstitial pneumonia (UIP). It …
progressive lung scarring and the histological picture of usual interstitial pneumonia (UIP). It …
Idiopathic pulmonary fibrosis
L Richeldi, HR Collard, MG Jones - The Lancet, 2017 - thelancet.com
Idiopathic pulmonary fibrosis is a prototype of chronic, progressive, and fibrotic lung disease.
Healthy tissue is replaced by altered extracellular matrix and alveolar architecture is …
Healthy tissue is replaced by altered extracellular matrix and alveolar architecture is …
SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis
Background Severe acute respiratory syndrome (SARS)-CoV-2-induced coronavirus
disease-2019 (COVID-19) is a pandemic disease that affects> 2.8 million people worldwide …
disease-2019 (COVID-19) is a pandemic disease that affects> 2.8 million people worldwide …
Developmental pathways in the pathogenesis of lung fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …