ANCA-associated vasculitis

AR Kitching, HJ Anders, N Basu, E Brouwer… - Nature reviews Disease …, 2020 - nature.com
The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are a
group of disorders involving severe, systemic, small-vessel vasculitis and are characterized …

A review of neutrophil extracellular traps (NETs) in disease: potential anti-NETs therapeutics

V Mutua, LJ Gershwin - Clinical reviews in allergy & immunology, 2021 - Springer
Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of
stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of …

The emerging role of neutrophil extracellular traps (NETs) in tumor progression and metastasis

MT Masucci, M Minopoli, S Del Vecchio… - Frontiers in …, 2020 - frontiersin.org
Neutrophil Extracellular Traps (NETs) are net-like structures composed of DNA-histone
complexes and proteins released by activated neutrophils. In addition to their key role in the …

Pathogenesis and therapeutic interventions for ANCA-associated vasculitis

D Nakazawa, S Masuda, U Tomaru… - Nature Reviews …, 2019 - nature.com
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) affects systemic
small vessels and is accompanied by the presence of ANCAs in the serum. This disease …

Neutrophil extracellular traps and their implications in cardiovascular and inflammatory disease

J Klopf, C Brostjan, W Eilenberg… - International journal of …, 2021 - mdpi.com
Neutrophils are primary effector cells of innate immunity and fight infection by phagocytosis
and degranulation. Activated neutrophils also release neutrophil extracellular traps (NETs) …

Neutrophil extracellular traps and its implications in inflammation: an overview

V Delgado-Rizo, MA Martínez-Guzmán… - Frontiers in …, 2017 - frontiersin.org
In addition to physical barriers, neutrophils are considered a part of the first line of immune
defense. They can be found in the bloodstream, with a lifespan of 6–8 h, and in tissue …

Neutrophil extracellular traps (NETs) in autoimmune diseases: a comprehensive review

KH Lee, A Kronbichler, DDY Park, YM Park, H Moon… - Autoimmunity …, 2017 - Elsevier
Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the
membranes of activated neutrophils. NETs are found in a variety of conditions such as …

Neutrophil extracellular traps in the second decade

V Brinkmann - Journal of innate immunity, 2018 - karger.com
Nearly 15 years after the first description of neutrophil extracellular traps (NETs), our
knowledge concerning this structure has expanded considerably. Initially, NETs were …

Increased neutrophil extracellular traps promote metastasis potential of hepatocellular carcinoma via provoking tumorous inflammatory response

LY Yang, Q Luo, L Lu, WW Zhu, HT Sun, R Wei… - Journal of hematology & …, 2020 - Springer
Background The propensity of the activated neutrophils to form extracellular traps (NETs) is
demonstrated in multiple inflammatory conditions. In this study, we investigated the roles of …

ANCA-associated vasculitis: an update

S Almaani, LA Fussner, S Brodsky, AS Meara… - Journal of clinical …, 2021 - mdpi.com
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) represents a group
of small vessel vasculitides characterized by granulomatous and neutrophilic tissue …