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[HTML][HTML] Beneficial effects of betaine: a comprehensive review
Medicinal herbs and many food ingredients possess favorable biological properties that
contribute to their therapeutic activities. One such natural product is betaine, a stable …
contribute to their therapeutic activities. One such natural product is betaine, a stable …
ISG15 in antiviral immunity and beyond
The host response to viral infection includes the induction of type I interferons and the
subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein …
subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein …
[HTML][HTML] ISG15: it's complicated
Interferon-stimulated gene product 15 (ISG15) is a key component of host responses to
microbial infection. Despite having been known for four decades, gras** the functions and …
microbial infection. Despite having been known for four decades, gras** the functions and …
ISG15: its roles in SARS-CoV-2 and other viral infections
Abstract Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like pleiotropic protein and
one of the most abundant ISGs, has been studied extensively; however, its roles in SARS …
one of the most abundant ISGs, has been studied extensively; however, its roles in SARS …
The diverse repertoire of ISG15: More intricate than initially thought
ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like
protein (UBL), which plays multifaceted roles not only as a free intracellular or extracellular …
protein (UBL), which plays multifaceted roles not only as a free intracellular or extracellular …
[HTML][HTML] Regulation of STING activity in DNA sensing by ISG15 modification
Sensing of human immunodeficiency virus type 1 (HIV-1) DNA is mediated by the cyclic
GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling axis. Signal …
GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling axis. Signal …
Viral pathogen-induced mechanisms to antagonize mammalian interferon (IFN) signaling pathway
Antiviral responses of interferons (IFNs) are crucial in the host immune response, playing a
relevant role in controlling viralw infections. Three types of IFNs, type I (IFN-α, IFN-β), II (IFN …
relevant role in controlling viralw infections. Three types of IFNs, type I (IFN-α, IFN-β), II (IFN …
RNase L amplifies interferon signaling by inducing protein kinase R-mediated antiviral stress granules
Virus infection leads to activation of the interferon (IFN)-induced endoribonuclease RNase L,
which results in degradation of viral and cellular RNAs. Both cellular and viral RNA cleavage …
which results in degradation of viral and cellular RNAs. Both cellular and viral RNA cleavage …
[HTML][HTML] Emerging roles of USP18: From biology to pathophysiology
Eukaryotic proteomes are enormously sophisticated through versatile post-translational
modifications (PTMs) of proteins. A large variety of code generated via PTMs of proteins by …
modifications (PTMs) of proteins. A large variety of code generated via PTMs of proteins by …
ISGylation in innate antiviral immunity and pathogen defense responses: a review
The interferon-stimulating gene 15 (ISG15) protein is a ubiquitin-like protein induced by
interferons or pathogens. ISG15 can exist in free form or covalently bind to the target protein …
interferons or pathogens. ISG15 can exist in free form or covalently bind to the target protein …