Low nephron number—resulting, for example, from prematurity or developmental anomalies—
is a risk factor for the development of hypertension, chronic kidney disease and kidney …

The adult mammalian kidney is a poorly regenerating organ that lacks the stem cells that
could replenish functional homeostasis similarly to, eg, skin or the hematopoietic system …

The current understanding of mammalian kidney development is largely based on mouse
models. Recent landmark studies revealed pervasive differences in renal embryogenesis …

Recent advances in the generation of kidney organoids and the culture of primary nephron
progenitors from mouse and human have been based on knowledge of the molecular basis …

Chronic kidney disease (CKD) and end stage renal disease (ESRD) are increasingly
frequent and devastating conditions that have driven a surge in the need for kidney …

Background The expression of CYP4Z1 and the pseudogene CYP4Z2P has been shown to
be specifically increased in breast cancer by our group and others. Additionally, we …

Background Nephron number is a major determinant of long-term renal function and
cardiovascular risk. Observational studies suggest that maternal nutritional and metabolic …

For decades, measurements of kidney microanatomy using 2-dimensional sections has
provided us with a detailed knowledge of kidney morphology under physiological and …

Mammalian nephron endowment is determined by the coordinated cessation of
nephrogenesis in independent niches. Here we report that translatome analysis in Tsc1+ …

Human urine is a non-invasive source of renal stem cells with regeneration potential. Urine-
derived renal progenitor cells were isolated from 10 individuals of both genders and distinct …