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Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments
The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …
related disorders remain unclear, but studies in depressed patients and rodent models are …
Mechanisms of ketamine action as an antidepressant
Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …
Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective
Major depressive disorder (MDD) is one of the most disabling psychiatric disorders.
Approximately one‐third of the patients with MDD are treatment resistant to the current …
Approximately one‐third of the patients with MDD are treatment resistant to the current …
[HTML][HTML] Cortical GABAergic dysfunction in stress and depression: new insights for therapeutic interventions
Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
The future of rodent models in depression research
Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …
burden of this debilitating disorder is anticipated to increase markedly over the coming …
NMDA receptor activation-dependent antidepressant-relevant behavioral and synaptic actions of ketamine
Ketamine is a well-characterized NMDA receptor (NMDAR) antagonist, although the
relevance of this pharmacology to its rapid (within hours of administration) antidepressant …
relevance of this pharmacology to its rapid (within hours of administration) antidepressant …
GABAA receptors as targets for treating affective and cognitive symptoms of depression
In the past 20 years, our understanding of the pathophysiology of depression has evolved
from a focus on an imbalance of monoaminergic neurotransmitters to a multifactorial picture …
from a focus on an imbalance of monoaminergic neurotransmitters to a multifactorial picture …
Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders
Cognitive dysfunctions, including impaired attention, learning, memory, planning and
problem solving, occur in depressive episodes, often persist during remission, predict …
problem solving, occur in depressive episodes, often persist during remission, predict …
Dual action of ketamine confines addiction liability
Ketamine is used clinically as an anaesthetic and a fast-acting antidepressant, and
recreationally for its dissociative properties, raising concerns of addiction as a possible side …
recreationally for its dissociative properties, raising concerns of addiction as a possible side …
Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …