Disorders of the nervous system are challenging to study and treat due to the relative
inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human …

The derivation of human embryonic stem cells (hESCs) and the stunning discovery that
somatic cells can be reprogrammed into human induced pluripotent stem cells (hiPSCs) …

The mechanisms by which common risk variants of small effect interact to contribute to
complex genetic disorders are unclear. Here, we apply a genetic approach, using isogenic …

Large-scale transcriptome studies with multiple samples per individual are widely used to
study disease biology. Yet, current methods for differential expression are inadequate for …

Aberrations in neurodevelopmental trajectories have been implicated in the neurobiology of
several mental disorders and evidence indicates a pathophysiological and genetic overlap …

Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …

Genome-wide association studies (GWAS) have reported substantial genomic loci
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …

Studies using induced pluripotent stem cells (iPSCs) are gaining momentum in brain
disorder modelling, but optimal study designs are poorly defined. Here, we compare …

Induced pluripotent stem cell (iPSC)-derived neurons are increasingly used to model Autism
Spectrum Disorder (ASD), which is clinically and genetically heterogeneous. To study the …

Psychiatric disorders are a heterogeneous group of mental disorders with abnormal mental
or behavioral patterns, which severely distress or disable affected individuals and can have …