A primer to directed evolution: current methodologies and future directions

LS Vidal, M Isalan, JT Heap… - RSC Chemical Biology, 2023 - pubs.rsc.org
Directed evolution is one of the most powerful tools for protein engineering and functions by
harnessing natural evolution, but on a shorter timescale. It enables the rapid selection of …

Genome size diversity and its impact on the evolution of land plants

J Pellicer, O Hidalgo, S Dodsworth, IJ Leitch - Genes, 2018 - mdpi.com
Genome size is a biodiversity trait that shows staggering diversity across eukaryotes, varying
over 64,000-fold. Of all major taxonomic groups, land plants stand out due to their …

From molecules to populations: appreciating and estimating recombination rate variation

JV Peñalba, JBW Wolf - Nature Reviews Genetics, 2020 - nature.com
Recombination is a central biological process with implications for many areas in the life
sciences. Yet we are only beginning to appreciate variation in the recombination rate along …

Using haplotype information for conservation genomics

M Leitwein, M Duranton, Q Rougemont… - Trends in ecology & …, 2020 - cell.com
The particular combinations of alleles that define haplotypes along individual chromosomes
can be determined with increasing ease and accuracy by using current sequencing …

Nanoparticles for vaccine and gene therapy: Overcoming the barriers to nucleic acid delivery

LM Mollé, CH Smyth, D Yuen… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Nucleic acid therapeutics can be used to control virtually every aspect of cell behavior and
therefore have significant potential to treat genetic disorders, infectious diseases, and …

Locally adaptive inversions modulate genetic variation at different geographic scales in a seaweed fly

C Mérot, EL Berdan, H Cayuela… - Molecular Biology …, 2021 - academic.oup.com
Across a species range, multiple sources of environmental heterogeneity, at both small and
large scales, create complex landscapes of selection, which may challenge adaptation …

Environmental adaptation of genetically uniform organisms with the help of epigenetic mechanisms—An insightful perspective on ecoepigenetics

G Vogt - Epigenomes, 2022 - mdpi.com
Organisms adapt to different environments by selection of the most suitable phenotypes from
the standing genetic variation or by phenotypic plasticity, the ability of single genotypes to …

Genomic features of parthenogenetic animals

KS Jaron, J Bast, RW Nowell… - Journal of …, 2021 - academic.oup.com
Evolution without sex is predicted to impact genomes in numerous ways. Case studies of
individual parthenogenetic animals have reported peculiar genomic features that were …

Practical considerations will ensure the continued success of pre-harvest biocontrol using non-aflatoxigenic Aspergillus flavus strains

GG Moore - Critical Reviews in Food Science and Nutrition, 2022 - Taylor & Francis
There is an important reason for the accelerated use of non-aflatoxigenic Aspergillus flavus
to mitigate pre-harvest aflatoxin contamination… it effectively addresses the imperative need …

Per-nucleus crossover covariation and implications for evolution

S Wang, C Veller, F Sun, A Ruiz-Herrera, Y Shang… - Cell, 2019 - cell.com
Crossing over is a nearly universal feature of sexual reproduction. Here, analysis of
crossover numbers on a per-chromosome and per-nucleus basis reveals a fundamental …