Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-
containing molecules that can induce DNA damage and affect the DNA damage response …

Mitogen‐activated protein kinase (MAPK) signaling pathways organize a great constitution
network that regulates several physiological processes, like cell growth, differentiation, and …

Checkpoint blockade immunotherapy enhances systemic antitumor immune response by
targeting T cell inhibitory pathways; however, inadequate T cell infiltration has limited its …

Histone posttranslational modifications are key components of diverse processes that
modulate chromatin structure. These marks function as signals during various chromatin …

DNA damage and neurodegenerative disorders are intimately linked but the underlying
mechanism remains elusive. Here, we show that persistent DNA lesions in tissue-resident …

Phosphorylation of the Ser-139 residue of the histone variant H2AX, forming γH2AX, is an
early cellular response to the induction of DNA double-strand breaks. Detection of this …

DNA damage is a key factor both in the evolution and treatment of cancer. Genomic
instability is a common feature of cancer cells, fuelling accumulation of oncogenic mutations …

Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …

DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …

Despite a conserved role for histones as general DNA packaging agents, it is now clear that
another key function of these proteins is to confer variations in chromatin structure to ensure …