The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Variation in the mitochondrial DNA (mtDNA) sequence is common in certain tumours. Two
classes of cancer mtDNA variants can be identified: de novo mutations that act as 'inducers' …

Anthracycline-based chemotherapy can result in the development of a cumulative and
progressively develo** cardiomyopathy. Doxorubicin is one of the most highly prescribed …

During tumorigenesis, cancer cells are exposed to a wide variety of intrinsic and extrinsic
stresses that challenge homeostasis and growth. Cancer cells display activation of distinct …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-develo**
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

Pivotal to projecting the fate of coral reefs is the capacity of reef-building corals to
acclimatize and adapt to climate change. Transgenerational plasticity may enable some …

Background: Limb muscle dysfunction is prevalent in chronic obstructive pulmonary disease
(COPD) and it has important clinical implications, such as reduced exercise tolerance …

Once considered exclusively the cell's powerhouse, mitochondria are now recognized to
perform multiple essential functions beyond energy production, impacting most areas of cell …