[HTML][HTML] ATP and adenosine—Two players in the control of seizures and epilepsy development
Despite continuous advances in understanding the underlying pathogenesis of
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …
Release of adenosine and ATP during ischemia and epilepsy
Eighty years ago Drury & Szent-Gyorgyi described the actions of adenosine, AMP (adenylic
acid) and ATP (pyrophosphoric or diphosphoric ester of adenylic acid) on the mammalian …
acid) and ATP (pyrophosphoric or diphosphoric ester of adenylic acid) on the mammalian …
The role of extracellular adenosine in chemical neurotransmission in the hippocampus and Basal Ganglia: pharmacological and clinical aspects
Now there is general agreement that the purine nucleoside adenosine is an important
neuromodulator in the central nervous system, playing a crucial role in neuronal excitability …
neuromodulator in the central nervous system, playing a crucial role in neuronal excitability …
A central role of connexin 43 in hypoxic preconditioning
JHC Lin, N Lou, N Kang, T Takano, F Hu… - Journal of …, 2008 - Soc Neuroscience
Preconditioning is an endogenous mechanism in which a nonlethal exposure increases
cellular resistance to subsequent additional severe injury. Here we show that connexin 43 …
cellular resistance to subsequent additional severe injury. Here we show that connexin 43 …
Metabolic aspects of adenosine functions in the brain
M Garcia-Gil, M Camici, S Allegrini, R Pesi… - Frontiers in …, 2021 - frontiersin.org
Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly,
plays a complex role in multiple physiological and pathophysiological processes by …
plays a complex role in multiple physiological and pathophysiological processes by …
Neuronal transporter and astrocytic ATP exocytosis underlie activity‐dependent adenosine release in the hippocampus
Key points• Using microelectrode biosensors we have directly measured the adenosine
release induced by focal stimulation in stratum radiatum of area CA1 in mouse hippocampal …
release induced by focal stimulation in stratum radiatum of area CA1 in mouse hippocampal …
ATP release during seizures–A critical evaluation of the evidence
Abstract That adenosine 5′ triphosphate (ATP) functions as an extracellular signaling
molecule has been established since the 1970s. Ubiquitous throughout the body as the …
molecule has been established since the 1970s. Ubiquitous throughout the body as the …
Effects of the ecto-ATPase apyrase on microglial ramification and surveillance reflect cell depolarization, not ATP depletion
C Madry, IL Arancibia-Cárcamo… - Proceedings of the …, 2018 - National Acad Sciences
Microglia, the brain's innate immune cells, have highly motile processes which constantly
survey the brain to detect infection, remove dying cells, and prune synapses during brain …
survey the brain to detect infection, remove dying cells, and prune synapses during brain …
K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study
BACKGROUND AND PURPOSE This study was undertaken to characterize the ATP,
adenosine and glutamate outflow evoked by depolarization with high K+ concentrations, in …
adenosine and glutamate outflow evoked by depolarization with high K+ concentrations, in …
Activity-dependent release of adenosine: a critical re-evaluation of mechanism
Adenosine is perhaps the most important and universal modulator in the brain. The current
consensus is that it is primarily produced in the extracellular space from the breakdown of …
consensus is that it is primarily produced in the extracellular space from the breakdown of …