Age-related macular degeneration (AMD) is a blinding eye disease which incidence
gradually increases with age. Inflammation participates in AMD pathogenesis, including …

Age-related macular degeneration (AMD) is the leading cause of visual impairment in the
aging population with a limited understanding of its pathogenesis and the number of …

In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …

Lipocalin 2 is a siderophore‐binding protein that regulates iron homeostasis. Lipocalin 2
expression is elevated in multiple tumor types; however, the mechanisms that drive tumor …

Non-neovascular or dry age-related macular degeneration (AMD) is a multi-factorial disease
with degeneration of the aging retinal-pigmented epithelium (RPE). Lysosomes play a …

Neovascular age-related macular degeneration (nvAMD) is the leading cause of blindness
in the elderly population. Although it is known that nvAMD is associated with focal …

Age-related macular degeneration (AMD) is the leading cause of vision loss and visual
impairment in people over 50 years of age. In the current therapeutic landscape, intravitreal …

Chronic (neuro) inflammation plays an important role in many age-related central nervous
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …

Immune dysfunction is widely regarded as one of the central tenants underpinning the
pathophysiology of diabetes mellitus (DM) and its complications. When discussing immunity …

Neutrophils are the most abundant human white blood cell and constitute a first line of
defense in the innate immune response. Neutrophils are short-lived cells and thus the …