The increasing threat to the human population posed by new or resurgent infectious
diseases, coupled with an alarming rise in the incidence of antibiotic-resistant microbes, has …

Publisher Summary This chapter discusses the rationale for develo** sporozoite vaccines.
Sporozoites are the infective stages of the parasite found in the salivary glands of female …

This study was designed to test the hypothesis that T-cell effector mechanisms are required
for protective immunity to malaria sporozoites. Administration of neutralizing monoclonal …

Twenty malaria-naive volunteers received a recombinant Plasmodium falciparum malaria
vaccine (RTS, S) containing 19 NANP repeats and the carboxy terminus (amino acids 210 …

Adeno-associated viruses (AAV) are ubiquitous in the human population (> 90% of adults
are seropositive) but have never been implicated as the cause of any disease. They were …

We have previously shown that a mixture of three synthetic peptides (83.1, 55.1, 35.1),
corresponding to fragments of the relative molecular mass 83,000 (83K), 55K and 35K …

A recombinant DNA Plasmodium falciparum sporozoite vaccine produced in Escherichia
coli (FSV-1) was tested in doses of 10 μg to 800 μg protein in fifteen volunteers. No serious …

An analysis of the known cytotoxic and helper T cell epitopes has revealed similarity within
their primary sequences. These similar motifs, characteristic of the known determinants …

The definition of human T-cell antigenic sites is important for subunit vaccine development of
a peptide immunogen if the goal is to allow antibody boosting during infection or to stimulate …

The malaria sporozoite vaccine candidate RTS, S, formulated with an oil-in-water emulsion
plus the immunostimulants monophosphoryl lipid A and the saponin derivative QS21 …