The activation strain or distortion/interaction model is a tool to analyze activation barriers that
determine reaction rates. For bimolecular reactions, the activation energies are the sum of …

Arynes are among the most active organic intermediates and have found numerous
applications in expeditious preparation of substituted arenes. In the past 20 years, chemists …

Method B 692 3.7. Selective Trifluoromethylation of Multi-Functional Substrates 693 3.8.
Enantioselective Trifluoromethylation 695 3.8. 1. Aldehydes and Ketones: With Cinchona …

Silver is a less expensive noble metal. Superior alkynophilicity due to π-coordination with
the carbon–carbon triple bond makes silver salts ideal catalysts for alkyne-based organic …

The hexadehydro-Diels–Alder (HDDA) reaction is the thermal cyclization of an alkyne and a
1, 3-diyne to generate a benzyne intermediate. This is then rapidly trapped, in situ, by a …

The ynamide functional group activates carbon–carbontriple bonds through an attached
nitrogen atom that bears an electron-withdrawing group. As a result, the alkyne has both …

The total syntheses of polycyclic natural products by exploiting an aryne as the key reactive
species are reviewed. A short introduction summarizes the basic reactivities of aryne …

Conspectus Arynes are highly reactive intermediates having several applications in organic
synthesis for the construction of various ortho-disubstituted arenes. Traditionally, arynes are …

Arynes hold significance for the efficient fusion of (hetero) arenes with diverse substrates,
advancing the construction of complex molecular frameworks. Employing multiple …

The synthesis of biaryls from benzyne intermediates offers an alternative strategy to
conventional metal-catalyzed cross-coupling approaches. The concept is as old as benzyne …