Doxorubicin—an agent with multiple mechanisms of anticancer activity

M Kciuk, A Gielecińska, S Mujwar, D Kołat… - Cells, 2023 - mdpi.com
Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens
currently in clinical use. However, the precise mechanisms of DOX's action are not fully …

Tumor-activated carrier-free prodrug nanoparticles for targeted cancer Immunotherapy: Preclinical evidence for safe and effective drug delivery

MK Shim, S Yang, IC Sun, K Kim - Advanced Drug Delivery Reviews, 2022 - Elsevier
As immunogenic cell death (ICD) inducers initiating antitumor immune responses, certain
chemotherapeutic drugs have shown considerable potential to reverse the …

Carrier-free nanomedicines for cancer treatment

LH Liu, XZ Zhang - Progress in Materials Science, 2022 - Elsevier
The last decade witnessed the great advances in the development of nanomedicines. As a
kind of attractive nanomedicine, carrier-free nanomedicines received extensive …

Nano delivery of chemotherapeutic ICD inducers for tumor immunotherapy

J Guo, Y Zou, L Huang - Small Methods, 2023 - Wiley Online Library
Immunogenic cell death (ICD, also known as immunogenic apoptosis) of malignant cells is
confirmed to activate the host immune system to prevent, control, and eliminate tumors …

Self‐Assembling Peptide‐Based Functional Biomaterials

Y Huo, J Hu, Y Yin, P Liu, K Cai, W Ji - ChemBioChem, 2023 - Wiley Online Library
Peptides can self‐assemble into various hierarchical nanostructures through noncovalent
interactions and form functional materials exhibiting excellent chemical and physical …

[HTML][HTML] Anti-PD-L1 peptide-conjugated prodrug nanoparticles for targeted cancer immunotherapy combining PD-L1 blockade with immunogenic cell death

Y Moon, MK Shim, J Choi, S Yang, J Kim, WS Yun… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Cancer immunotherapy combining immune checkpoint blockade (ICB) with
chemotherapeutic drugs has provided significant clinical advances. However, such …

Photothermal “nano-dot” reactivate “immune-hot” for tumor treatment via reprogramming cancer cells metabolism

Y Lu, Y Wang, W Liu, H Ma, B Yang, K Shao, S Long… - Biomaterials, 2023 - Elsevier
Cancer immunotherapy, despite its enormous application prospect, is trapped in the
abnormal lactic acid metabolism of tumor cells that usually causes an immunosuppressive …

Doxorubicin prodrug-based nanomedicines for the treatment of cancer

H Zhao, J Yu, R Zhang, P Chen, H Jiang… - European journal of …, 2023 - Elsevier
The chemotherapeutic drug of doxorubicin (DOX) has witnessed widespread applications
for treating various cancers. DOX-treated dying cells bear cellular modifications which allow …

Polymeric STING Pro‐agonists for Tumor‐Specific Sonodynamic Immunotherapy

J Yu, S He, C Zhang, C Xu, J Huang, M Xu… - Angewandte …, 2023 - Wiley Online Library
The efficacy of combination immunotherapy has been limited by tumor specificity and
immune‐related adverse events (irAEs). Herein, we report the development of polymeric …

Recent progress, perspectives, and issues of engineered PD-L1 regulation nano-system to better cure tumor: A review

Z Zhou, H Wang, J Li, X Jiang, Z Li, J Shen - International Journal of …, 2024 - Elsevier
Currently, immune checkpoint blockade (ICB) therapies that target the programmed cell
death ligand-1 (PD-L1) have been used as revolutionary cancer treatments in the clinic …