Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria

H Liu, Z Hu, M Li, Y Yang, S Lu, X Rao - Journal of biomedical science, 2023 - Springer
Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …

Antimicrobial resistance and recent alternatives to antibiotics for the control of bacterial pathogens with an emphasis on foodborne pathogens

YA Helmy, K Taha-Abdelaziz, HAEH Hawwas, S Ghosh… - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance (AMR) is one of the most important global public health problems.
The imprudent use of antibiotics in humans and animals has resulted in the emergence of …

The Continuing Threat of Methicillin-Resistant Staphylococcus aureus

M Gajdács - Antibiotics, 2019 - mdpi.com
Staphylococcus aureus has been an exceptionally successful pathogen, which is still
relevant in modern age-medicine due to its adaptability and tenacity. This bacterium may be …

Potential impact of the multi-target drug approach in the treatment of some complex diseases

XH Makhoba, C Viegas Jr, RA Mosa… - Drug design …, 2020 - Taylor & Francis
It is essential to acknowledge the efforts made thus far to manage or eliminate various
disease burden faced by humankind. However, the rising global trends of the so-called …

Phage-encoded endolysins

F Abdelrahman, M Easwaran, OI Daramola, S Ragab… - Antibiotics, 2021 - mdpi.com
Due to the global emergence of antibiotic resistance, there has been an increase in
research surrounding endolysins as an alternative therapeutic. Endolysins are phage …

The concept of an ideal antibiotic: implications for drug design

M Gajdács - Molecules, 2019 - mdpi.com
The emergence and spread of antibiotic-resistant pathogens is a major public health issue,
which requires global action of an intersectoral nature. Multidrug-resistant (MDR) pathogens …

Endolysin, a promising solution against antimicrobial resistance

M Rahman, W Wang, Q Sun, JA Shah, C Li, Y Sun, Y Li… - Antibiotics, 2021 - mdpi.com
Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the
effective prevention and control of ever-increasing infectious diseases. The advent of …

Bacteriophages as alternatives to antibiotics in clinical care

D Romero-Calle, R Guimarães Benevides… - Antibiotics, 2019 - mdpi.com
Antimicrobial resistance is increasing despite new treatments being employed. With a
decrease in the discovery rate of novel antibiotics, this threatens to take humankind back to …

Treating bacterial infections with bacteriophage-based enzybiotics: in vitro, in vivo and clinical application

KM Danis-Wlodarczyk, DJ Wozniak, ST Abedon - Antibiotics, 2021 - mdpi.com
Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …

[HTML][HTML] Bacteriophages—a new hope or a huge problem in the food industry

M Połaska, B Sokołowska - AIMS microbiology, 2019 - ncbi.nlm.nih.gov
Bacteriophages are viruses that are ubiquitous in nature and infect only bacterial cells.
These organisms are characterized by high specificity, an important feature that enables …