NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that
time, it has been found to have a broad role in gene induction in diverse cellular responses …

Patients with a diverse spectrum of rare genetic disorders can present with inflammatory
bowel disease (monogenic IBD). Patients with these disorders often develop symptoms …

Simple Summary In this review paper, we explore the role of chronic inflammation in the
pathogenesis of prostatic diseases, such as chronic prostatitis, benign prostatic hyperplasia …

Toll-like receptors (TLRs) are pattern recognition receptors that play a central role in the
development and function of the immune system. TLR signaling promotes the earliest …

The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …

Autosomal recessive IRAK-4 and MyD88 deficiencies predispose affected patients to
recurrent invasive pyogenic bacterial infection. Both defects result in the selective …

Autosomal recessive interleukin-1 receptor-associated kinase (IRAK)-4 and myeloid
differentiation factor (MyD) 88 deficiencies impair Toll-like receptor (TLR)-and interleukin-1 …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb) and a few related
mycobacteria, is a devastating disease, killing more than a million individuals per year …

3. Doffinger R, Smahi A, Bessia C, Geissmann F, Feinberg J, Durandy A, et al. X-linked
anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB …