The function and regulation of zinc in the brain
RF Krall, T Tzounopoulos, E Aizenman - Neuroscience, 2021 - Elsevier
Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …
Understanding the role of GPCR heteroreceptor complexes in modulating the brain networks in health and disease
DO Borroto-Escuela, J Carlsson… - Frontiers in cellular …, 2017 - frontiersin.org
The introduction of allosteric receptor–receptor interactions in G protein-coupled receptor
(GPCR) heteroreceptor complexes of the central nervous system (CNS) gave a new …
(GPCR) heteroreceptor complexes of the central nervous system (CNS) gave a new …
Zinc and central nervous system disorders
B Wang, T Fang, H Chen - Nutrients, 2023 - mdpi.com
Zinc (Zn2+) is the second most abundant necessary trace element in the human body,
exerting a critical role in many physiological processes such as cellular proliferation …
exerting a critical role in many physiological processes such as cellular proliferation …
Zinc in the monoaminergic theory of depression: its relationship to neural plasticity
Preclinical and clinical studies have demonstrated that zinc possesses antidepressant
properties and that it may augment the therapy with conventional, that is, monoamine …
properties and that it may augment the therapy with conventional, that is, monoamine …
[HTML][HTML] Interaction between zinc, GPR39, BDNF and neuropeptides in depression
K Mlyniec - Current Neuropharmacology, 2021 - ncbi.nlm.nih.gov
As one of the most important elements in our body, zinc plays a part in both the
pathophysiology of depression and the antidepressant response. Patients suffering from …
pathophysiology of depression and the antidepressant response. Patients suffering from …
Interaction between zinc, the GPR39 zinc receptor and the serotonergic system in depression
Zinc signalling has a crucial impact on the proper functioning of the brain. Disturbances
within the zincergic system may lead to neuropsychological disorders, including major …
within the zincergic system may lead to neuropsychological disorders, including major …
Long-lasting antidepressant-like activity of the GPR39 zinc receptor agonist TC-G 1008
G Starowicz, M Jarosz, E Frąckiewicz… - Journal of Affective …, 2019 - Elsevier
Background The discovery of the zinc-sensing receptor, has provided new possibilities for
explaining the neurobiology of zinc. Recent studies indicate that the GPR39 zinc receptor …
explaining the neurobiology of zinc. Recent studies indicate that the GPR39 zinc receptor …
Dietary zinc differentially regulates the effects of the GPR39 receptor agonist, TC-G 1008, in the maximal electroshock seizure test and pentylenetetrazole-kindling …
U Doboszewska, K Socała, M Pieróg, D Nieoczym… - Cells, 2023 - mdpi.com
The G-protein coupled receptor 39 (GPR39) is gaining increasing attention as a target for
future drugs, yet there are gaps in the understanding of its pharmacology. Zinc is an …
future drugs, yet there are gaps in the understanding of its pharmacology. Zinc is an …
[HTML][HTML] Galanin receptor 3− A new pharmacological target in retina degeneration
The neuropeptide galanin receptor 3 (GALR3) is a class AG protein-coupled receptor
(GPCR) broadly expressed in the nervous system, including the retina. GALR3 is involved in …
(GPCR) broadly expressed in the nervous system, including the retina. GALR3 is involved in …
Concentration-dependent dual mode of Zn action at serotonin 5-HT1A receptors: in vitro and in vivo studies
G Satała, B Duszyńska, K Stachowicz, A Rafalo… - Molecular …, 2016 - Springer
Recent data has indicated that Zn can modulate serotonergic function through the 5-HT 1A
receptor (5-HT 1A R); however, the exact mechanisms are unknown. In the present studies …
receptor (5-HT 1A R); however, the exact mechanisms are unknown. In the present studies …