Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug
administration routes. Oral and injectable drug administration are the most common routes …

Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

Nanosponges are nanosized drug carriers with a three-dimensional structure created by
crosslinking polymers. They have the advantage of being able to hold a wide range of drugs …

Intravitreal injections (IVT) are regarded as the gold standard for effective delivery of
hydrophobic drugs to the back of the eye. However, as a highly invasive procedure, the …

Ellagic acid (EA) is a polyphenolic active compound with antimalarial and other promising
therapeutic activities. However, its solubility and its permeability are both low (BCS IV) …

Cancer continues to be one of the most common causes of mortality globally, claiming
approximately eight million lives each year. Chemotherapy is the primary treatment protocol; …

Increasing the sustainability of industrial processes implies the substitution of conventional
solvents for others with less environmental impact. For its implementation, it is essential to …

The oral route is the preferred way of drug administration for most drugs, whose treatment
success is directly related to the compound intestinal absorption. This absorption process, in …

Novel p-coumaric acid microemulsion systems were developed to circumvent its absorption
and bioavailability challenges. Simplex-lattice mixture design and machine learning …

The success of obtaining solid dispersions for solubility improvement invariably depends on
the miscibility of the drug and polymeric carriers. This study aimed to categorize and select …