High-resolution native mass spectrometry
Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …
Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment
The tumor microenvironment is crucial for the growth of cancer cells, triggering particular
biochemical and physiological changes, which frequently influence the outcome of …
biochemical and physiological changes, which frequently influence the outcome of …
Mass spectrometry of nucleic acid noncovalent complexes
Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
Experimental carbonic anhydrase inhibitors for the treatment of hypoxic tumors
CT Supuran - Journal of Experimental Pharmacology, 2020 - Taylor & Francis
Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) isoforms IX and XII are overexpressed in
many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation …
many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation …
Tips on making tiny tips: Secrets to submicron nanoelectrospray emitters
Nanoelectrospray ionization emitters with submicron tip diameters have significant
advantages for use in native mass spectrometry, including the ability to produce resolved …
advantages for use in native mass spectrometry, including the ability to produce resolved …
Is Native Mass Spectrometry in Ammonium Acetate Really Native? Protein Stability Differences in Biochemically Relevant Salt Solutions
Ammonium acetate is widely used in native mass spectrometry to provide adequate ionic
strength without adducting to protein ions, but different ions can preferentially stabilize or …
strength without adducting to protein ions, but different ions can preferentially stabilize or …
Solution and Gas-Phase Stability of DNA Junctions from Temperature-Controlled Electrospray Ionization and Surface-Induced Dissociation
DNA three-way junction (TWJ) structures transiently form during key cellular processes such
as transcription, replication, and DNA repair. Despite their significance, the thermodynamics …
as transcription, replication, and DNA repair. Despite their significance, the thermodynamics …
Lighting Up at High Potential: Effects of Voltage and Emitter Size in Nanoelectrospray Ionization
Effects of electrospray voltage on cluster size and abundance formed from aqueous CsI
were investigated with emitter tip diameters between 260±7 nm and 2.45±0.30 μm. Cluster …
were investigated with emitter tip diameters between 260±7 nm and 2.45±0.30 μm. Cluster …
Perfluoroalkyl substances of significant environmental concern can strongly inhibit human carbonic anhydrase isozymes
Perfluoroalkyl substances (PFASs) persist and are ubiquitous in the environment. The
origins of PFAS toxicity and how they specifically affect the functions of proteins remain …
origins of PFAS toxicity and how they specifically affect the functions of proteins remain …