The most commonly reported immunological abnormality in Type I diabetes mellitus is
autoantibodies reacting with pancreatic islet-cell antigens [reviewed in 2, 6, 11-13]. These …

Type 1 diabetes is an autoimmune disease caused by the immune‐mediated destruction of
insulin‐producing pancreatic β cells. In recent years, the incidence of type 1 diabetes …

Autoimmune diseases are chronic conditions resulting from a loss of immunological
tolerance to self‐antigens. Recent observations have supported an ever‐broader role for …

The NK1. 1 cell surface receptor, which belongs to the NKR-P1 gene cluster, has been bred
onto nonobese diabetic (NOD) mice for two purposes. The first was to tag NK and NKT cells …

Peripheral blood mononuclear cells from 20 Type 1 (insulin-dependent) diabetic patients
were examined for natural killer cell activity using the K562 cell line as 51 Cr labeled targets …

Type 1 diabetes (T1D) is characterized by an immuno‐mediated progressive destruction of
the pancreatic β cells. Due to the ability of NK cells to kill target cells as well as to interact …

Viruses may cause Type 1 (insulin-dependent) diabetes. We wondered whether the number
and function of natural killer cells, which are important in anti-viral defense, are disturbed in …

Natural killer (NK) cells belong to the innate lymphoid cells. Their cytotoxic activity is
regulated by the delicate balance between activating and inhibitory signals. NKp46 is a …

Type 1 diabetes mellitus (T1DM) is characterized by absolute insulin deficiency owing to
autoimmune destruction of the pancreatic β cells. A significant decrease in natural killer (NK) …

Peripheral blood lymphocytes from 13 patients with established insulin-dependent diabetes
mellitus (IDDM) and 2 prediabetic patients were examined for natural killer (NK) and …