[HTML][HTML] Tryptophan metabolism: a link between the gut microbiota and brain

K Gao, C Mu, A Farzi, W Zhu - Advances in nutrition, 2020 - Elsevier
The gut-brain axis (GBA) is a bilateral communication network between the gastrointestinal
(GI) tract and the central nervous system. The essential amino acid tryptophan contributes to …

Gut microbiota regulation of tryptophan metabolism in health and disease

A Agus, J Planchais, H Sokol - Cell host & microbe, 2018 - cell.com
The gut microbiota is a crucial actor in human physiology. Many of these effects are
mediated by metabolites that are either produced by the microbes or derived from the …

Honeybee gut Lactobacillus modulates host learning and memory behaviors via regulating tryptophan metabolism

Z Zhang, X Mu, Q Cao, Y Shi, X Hu, H Zheng - Nature Communications, 2022 - nature.com
Honeybees are highly social insects with a rich behavioral repertoire and are a versatile
model for neurobiological research. Their gut microbiota comprises a limited number of host …

Indole-3-propionic acid protects against heart failure with preserved ejection fraction

YC Wang, YC Koay, C Pan, Z Zhou, W Tang… - Circulation …, 2024 - ahajournals.org
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a common but
poorly understood form of heart failure, characterized by impaired diastolic function. It is …

Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders

M Scuto, F Rampulla, GM Reali, SM Spanò… - Antioxidants, 2024 - mdpi.com
The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress
resilience and overall human health have received much attention. Recently, the gut–brain …

[HTML][HTML] Production of indole and indole-related compounds by the intestinal microbiota and consequences for the host: the good, the bad, and the ugly

N Tennoune, M Andriamihaja, F Blachier - Microorganisms, 2022 - mdpi.com
The intestinal microbiota metabolic activity towards the available substrates generates
myriad bacterial metabolites that may accumulate in the luminal fluid. Among them, indole …

Associations of dietary patterns with brain health from behavioral, neuroimaging, biochemical and genetic analyses

R Zhang, B Zhang, C Shen, BJ Sahakian, Z Li… - Nature Mental …, 2024 - nature.com
Food preferences significantly influence dietary choices, yet understanding natural dietary
patterns in populations remains limited. Here we identifiy four dietary subtypes by applying …

Gut dysbiosis in Huntington's disease: associations among gut microbiota, cognitive performance and clinical outcomes

CI Wasser, EC Mercieca, G Kong… - Brain …, 2020 - academic.oup.com
Huntington's disease is characterized by a triad of motor, cognitive and psychiatric
impairments, as well as unintended weight loss. Although much of the research has focused …

Systemic tryptophan homeostasis

S Klaessens, V Stroobant, E De Plaen… - Frontiers in molecular …, 2022 - frontiersin.org
Tryptophan is an essential amino acid, which is not only a building block for protein
synthesis, but also a precursor for the biosynthesis of co-enzymes and neuromodulators …

Gut‐liver axis‐mediated mechanism of liver cancer: a special focus on the role of gut microbiota

N Ohtani, E Hara - Cancer science, 2021 - Wiley Online Library
Gut microbiota and the mammalian host share a symbiotic relationship, in which the host
provides a suitable ecosystem for the gut bacteria to digest indigestible nutrients and …