Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of children in the pediatric intensive care unit

JD Tobias - Critical care medicine, 2000 - journals.lww.com
Tolerance, withdrawal, and physical dependency after long-te... : Critical Care Medicine
Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of …

NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders

JH Krystal, DC D'Souza, IL Petrakis… - Harvard review of …, 1999 - Taylor & Francis
Antagonists of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors and
agonist of the glycine-B coagnoist site of these receptors have been important tools for …

The effects of NMDA receptor antagonists and nitric oxide synthase inhibitors on opioid tolerance and withdrawal

BH Herman, F Vocci, P Bridge - Neuropsychopharmacology, 1995 - nature.com
This article is an exploration of the National Institute on Drug Abuse (NIDA) Technical
Review on the role of glutamatergic systems in the development of opiate addiction. The …

Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study

GK Aghajanian, JH Kogan, B Moghaddam - Brain research, 1994 - Elsevier
Electrophysiological studies suggest that an increase in excitatory amino acid release may
occur in the locus coeruleus during opiate withdrawal. The present study examined directly …

Excitatory amino acids and drugs of abuse: a role for N-methyl-D-aspartate receptors in drug tolerance, sensitization and physical dependence

KA Trujillo, H Akil - Drug and alcohol dependence, 1995 - Elsevier
N-methyl-d-aspartate (NMDA) receptors have been implicated in several types of neural and
behavioral plasticity ranging from development to learning. The present paper reviews …

Are NMDA receptors involved in opiate-induced neural and behavioral plasticity? A review of preclinical studies

KA Trujillo - Psychopharmacology, 2000 - Springer
Rationale: Research over the past decade demonstrating that NMDA receptor antagonists
have the ability to inhibit opiate tolerance, sensitization and physical dependence has led to …

Changes in the expression of glial glutamate transporters in the rat brain accompanied with morphine dependence and naloxone-precipitated withdrawal

T Ozawa, T Nakagawa, K Shige, M Minami, M Satoh - Brain research, 2001 - Elsevier
The expression of mRNAs for the glial glutamate transporters, GLT-1 and GLAST, in the rat
brain accompanied with morphine dependence and naloxone-precipitated withdrawal was …

Role of orexin type-1 receptors in paragiganto-coerulear modulation of opioid withdrawal and tolerance: a site specific focus

SM Ahmadi-Soleimani, H Azizi, HS Gompf… - …, 2017 - Elsevier
Orexin-A and-B neuropeptides are exclusively synthesized in hypothalamic neurons. These
have been implicated to play critical roles in the expression of various behavioral …

In vivo electrophysiological recordings of the effects of antidepressant drugs

PJ Fitzgerald, BO Watson - Experimental Brain Research, 2019 - Springer
Antidepressant drugs are a standard biological treatment for various neuropsychiatric
disorders, yet relatively little is known about their electrophysiologic and synaptic effects on …

[PDF][PDF] Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614.

PJ Tiseo, CE Inturrisi - Journal of Pharmacology and Experimental …, 1993 - Citeseer
The ability of a competitive(LY27461 4;(±)-6-phosphonomethyldecahydroisoquinolin-3-
carboxylic acid) and a noncompetitive (MK8OI;[(+)-5 methyl-1O, 1 1-dihydro-5H-dibenzo [a …