Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates …

Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

Astrocytes are emerging in the neuroscience field as crucial modulators of brain functions,
from the molecular control of synaptic plasticity to orchestrating brain-wide circuit activity for …

Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …

The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …

Elucidating the roles of neuronal cell types for physiology and behavior is essential for
understanding brain functions. Perturbation of neuron electrical activity can be used to probe …

Experimental models of epilepsy are useful to identify potential mechanisms of
epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) …

After an initial period of recovery, human neurological injury has long been thought to be
static. In order to improve quality of life for those suffering from stroke, spinal cord injury, or …

Descriptions of epileptic seizures and epilepsy date back to antiquity, and research into
fundamental mechanisms of epilepsy in animal models, as well as patients, has been …

Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …