The merger of photoredox catalysis with transition metal catalysis, termed
metallaphotoredox catalysis, has become a mainstay in synthetic methodology over the past …

Benzenes, the most ubiquitous structural moiety in marketed small-molecule drugs, are
frequently associated with poor 'drug-like'properties, including metabolic instability, and poor …

The development of synthetic strategies for the preparation of bioisosteric compounds is a
demanding undertaking in medicinal chemistry. Numerous strategies have been developed …

Thermal C–C bond cleavage reactions allow the construction of structurally diverse
molecular skeletons via predictable and efficient bond reorganizations. Visible light …

Synthesis of bicyclic scaffolds has attracted growing interest because they are of high
importance in modern pharmaceutical development. Here we report a strategy to access …

The unique chemistry of small, strained carbocyclic systems has long captivated organic
chemists from a theoretical and fundamental standpoint. A resurgence of interest in strained …

Aliphatic three-and four-membered rings including cyclopropanes, cyclobutanes, oxetanes,
azetidines and bicyclo [1.1. 1] pentanes have been increasingly exploited in medicinal …

Synthesis of bicyclic scaffolds has attracted tremendous attention because they are playing
an important role as saturated bioisosteres of benzenoids in modern drug discovery. Here …

Bridged cyclobutanes and sulfur heterocycles are currently under intense investigation as
building blocks for pharmaceutical drug design. Two formal cycloaddition modes involving …

Strained bicyclic substructures are increasingly relevant in medicinal chemistry discovery
research because of their role as bioisosteres. Over the last decade, the successful use of …