Non-small cell lung cancer (NSCLC) is characterized by molecular heterogeneity with
diverse immune cell infiltration patterns, which has been linked to therapy sensitivity and …

Biological systems are immensely complex, organized into a multi-scale hierarchy of
functional units based on tightly regulated interactions between distinct molecules, cells …

Immune checkpoint inhibitor (ICI) therapy can induce complete responses in mismatch
repair-deficient and microsatellite instability-high (d-MMR/MSI-H) colorectal cancers (CRCs) …

Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSCs) acquire mutations,
most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage …

The notion of exploiting the regenerative potential of the human brain in physiological aging
or neurological diseases represents a particularly attractive alternative to conventional …

Ambient RNA contamination in single-cell and single-nuclei RNA sequencing (snRNA-seq)
is a significant problem, but its consequences are poorly understood. Here, we show that …

Brassinosteroids are plant steroid hormones that regulate diverse processes, such as cell
division and cell elongation, through gene regulatory networks that vary in space and time …

Morphogens choreograph the generation of remarkable cellular diversity in the develo**
nervous system. Differentiation of stem cells in vitro often relies upon the combinatorial …

Single-cell analysis is currently one of the most high-resolution techniques to study biology.
The large complex datasets that have been generated have spurred numerous …

Pathogenic α-synuclein and tau are critical drivers of neurodegeneration, and their
mutations cause neuronal loss in patients. Whether the underlying preferential neuronal …