The combination of computational models and biophysical simulations can help to interpret
an array of experimental data and contribute to the understanding, diagnosis and treatment …

Cardiac muscle contraction is a strictly regulated process which conjugates a series of
electrophysiological, biochemical and mechanic events, resulting in the pum** of blood to …

Whereas the two-dimensional (2D) visualisation of biological samples is routine, three-
dimensional (3D) imaging remains a time-consuming and relatively specialised pursuit …

Cardiac architecture is fundamental to cardiac function and can be assessed non-invasively
with diffusion tensor imaging (DTI). Here, we aimed to overcome technical challenges in ex …

Myocardial remodelling involves not only the myocytes, but also non-myocyte cells and the
extracellular matrix, which constitutes around 6% of the normal heart and includes fluid …

Both biomedical research and clinical practice rely on complex datasets for the physiological
and genetic characterization of human hearts in health and disease. Given the complexity …

Diffusion tensor magnetic resonance imaging (MRI) reveals valuable insights into tissue
histo-anatomy and microstructure, and has steadily gained traction in the cardiac …

Traditional histology is the gold standard for tissue studies, but it is intrinsically reliant on two-
dimensional (2D) images. Study of volumetric tissue samples such as whole hearts …

Myocardial microstructure and its macroscopic materialisation are fundamental to the
function of the heart. Despite this importance, characterisation of cellular features at the …

BACKGROUND: Cardiac magnetic resonance imaging (CMR)–defined ventricular scar and
anatomic conduction channels (CMR-CCs) offer promise in delineating ventricular …