Müller cells are active players in normal retinal function and in virtually all forms of retinal
injury and disease. Reactive Müller cells protect the tissue from further damage and …

Stem cell therapies are being explored extensively as treatments for degenerative eye
disease, either for replacing lost neurons, restoring neural circuits or, based on more recent …

Despite different aetiologies, age-related macular degeneration and most inherited retinal
disorders culminate in the same final common pathway, the loss of photoreceptors. There …

Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …

It has long been believed that the retina of mature mammals is incapable of regeneration. In
this study, using the N-methyl-d-aspartate neurotoxicity model of adult rat retina, we …

The regenerative capacity of the CNS is extremely limited. The reason for this is unclear, but
glial cell involvement has been suspected, and oligodendrocytes have been implicated as …

Ex vivo cultured limbal epithelial stem cells have been used successfully to treat corneal
limbal stem cell deficiency. We identified 17 reports of the application of this novel cell …

Growing evidence suggests that glial cells may have a role as neural precursors in the adult
central nervous system. Although it has been shown that Müller cells exhibit progenitor …

The aim of this study was to investigate the role of microglia in radiation-induced astrocyte
gliosis. We found that a single dose of 15 Gy radiation to a whole rat brain increased …

Retinal degenerations and dystrophies are the major causes of genetically inherited
blindness that are characterized by the apoptotic death of the photoreceptor cell layer of the …