Langerhans cell histiocytosis (LCH) is a rare systemic disorder characterized by the
accumulation of CD 1a+/Langerin+ LCH cells and wide‐ranging organ involvement …

Pulmonary Langerhans cell histiocytosis (PLCH) is a diffuse lung disease that usually affects
young adult smokers. PLCH affects different lung compartments; bronchiolar, interstitial and …

Langerhans cell histiocytosis (LCH) can affect children and adults with a wide variety of
clinical manifestations, including unifocal, single-system multifocal, single-system pulmonary …

Rosai–Dorfman disease is a histiocytic disorder with a poorly defined pathogenesis. Recent
molecular studies have revealed recurrent mutations involving genes in the MAPK/ERK …

Histiocytic neoplasms, a rare and heterogeneous group of disorders, primarily include
Erdheim-Chester disease, Langerhans cell histiocytosis, and Rosai-Dorfman disease. Due …

Langerhans cell histiocytosis (LCH) comprises a wide spectrum of clinical disorders that
have in common a proliferation of Langerhans-type cells with characteristic morphologic …

Tobacco exposure results in various changes to the airways and lung parenchyma.
Although emphysema represents the more common injury pattern, in some individuals …

Langerhans cell histiocytosis (LCH) is a disease characterized by clonal proliferation of
CD1a1/CD2071 myeloid dendritic cells that presents at all ages and with different degrees …

The mitogen-activated protein kinase (MAPK) pathway is constantly activated in Langerhans
cell histiocytosis (LCH). Mutations of the downstream kinases BRAF and MAP2K1 mediate …

Context Pulmonary Langerhans cell histiocytosis (PLCH) is a rare histiocytic disorder that
almost exclusively affects the lungs of smokers. PLCH is characterized by bronchiolocentric …