Lipid metabolic vulnerabilities of multiple myeloma

R Torcasio, ME Gallo Cantafio, RK Ikeda… - Clinical and …, 2023 - Springer
Multiple myeloma (MM) is the second most common hematological malignancy worldwide,
characterized by abnormal proliferation of malignant plasma cells within a tumor-permissive …

Next generation thiazolyl ketone inhibitors of cytosolic phospholipase A2 α for targeted cancer therapy

FJ Ashcroft, A Bourboula, N Mahammad… - Nature …, 2025 - nature.com
Eicosanoids are key players in inflammatory diseases and cancer. Targeting their
production by inhibiting Group IVA cytosolic phospholipase A2 (cPLA2α) offers a promising …

Comprehensive analysis of prognosis of cuproptosis-related oxidative stress genes in multiple myeloma

T Li, L Yao, Y Hua, Q Wu - Frontiers in Genetics, 2023 - frontiersin.org
Introduction: Multiple myeloma (MM) is a highly heterogeneous hematologic malignancy.
The patients' survival outcomes vary widely. Establishing a more accurate prognostic model …

Next Generation Thiazolyl Ketone Inhibitors of Cytosolic Phospholipase A2 α: from Synthesis to Chemotherapeutic Mechanism of Action

B Johansen, F Ashcroft, A Bourmpoula, N Mahammad… - 2023 - researchsquare.com
Eicosanoids regulate the pathologies of inflammation and carcinogenesis and limiting their
production by inhibiting group IVA cytosolic phospholipase A2 (cPLA2α) is a potential …