Insights from inherited forms of parkinsonism suggest that insufficient mitophagy may be one
etiology of the disease. PINK1/Parkin-dependent mitophagy, which helps maintain a healthy …

Protein homeostasis (proteostasis) requires the timely degradation of misfolded proteins and
their aggregates by protein quality control (PQC), of which molecular chaperones are an …

Ubiquitin (Ub) chain formation by homologous to E6AP C-terminus (HECT)-family E3 ligases
regulates vast biology, yet the structural mechanisms remain unknown. We used chemistry …

The ongoing epidemic of Zika virus (ZIKV) illustrates the importance of flaviviruses as
emerging human pathogens. All vector-borne flaviviruses studied thus far have to overcome …

Background There are currently no disease-modifying therapeutics for Parkinson's disease
(PD). Although extensive efforts were undertaken to develop therapeutic approaches to …

Proteolysis in eukaryotic cells is mainly mediated by the ubiquitin (Ub)-proteasome system
(UPS) and the autophagylysosome system (hereafter autophagy). The UPS is a selective …

PINK1, a mitochondrial serine/threonine kinase, is the product of a gene mutated in an
autosomal recessive form of Parkinson disease. PINK1 is constitutively degraded by an …

Specificity of eukaryotic protein degradation is determined by E3 ubiquitin ligases and their
selective binding to protein motifs, termed" degrons," in substrates for ubiquitin-mediated …

Induced protein degradation accomplishes elimination, rather than inhibition, of pathological
proteins. Key to the success of this novel therapeutic modality is the modification of proteins …

The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …