Mendelian randomization
Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …
address causal questions about how modifiable exposures influence different outcomes …
Mendelian randomization: concepts and scope
RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
Causal relationship between physical activity, leisure sedentary behaviors and COVID-19 risk: a Mendelian randomization study
X Chen, X Hong, W Gao, S Luo, J Cai, G Liu… - Journal of translational …, 2022 - Springer
Background The 2019 coronavirus disease pandemic (COVID-19) poses an enormous
threat to public health worldwide, and the ensuing management of social isolation has …
threat to public health worldwide, and the ensuing management of social isolation has …
Guidelines for performing Mendelian randomization investigations: update for summer 2023
This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …
aimed at practitioners seeking to undertake analyses and write up their findings, and at …
[HTML][HTML] Using genetic association data to guide drug discovery and development: review of methods and applications
Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …
expensive and slow to obtain. In contrast, evidence from conventional observational …
[HTML][HTML] Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
Estimates from Mendelian randomization studies of unrelated individuals can be biased due
to uncontrolled confounding from familial effects. Here we describe methods for within-family …
to uncontrolled confounding from familial effects. Here we describe methods for within-family …
[HTML][HTML] Statistical methods for Mendelian randomization in genome-wide association studies: a review
Genome-wide association studies have yielded thousands of associations for many
common diseases and disease-related complex traits. The identified associations made it …
common diseases and disease-related complex traits. The identified associations made it …
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
Horizontal pleiotropy occurs when the variant has an effect on disease outside of its effect on
the exposure in Mendelian randomization (MR). Violation of the 'no horizontal …
the exposure in Mendelian randomization (MR). Violation of the 'no horizontal …
Mendelian randomisation for mediation analysis: current methods and challenges for implementation
Mediation analysis seeks to explain the pathway (s) through which an exposure affects an
outcome. Traditional, non-instrumental variable methods for mediation analysis experience …
outcome. Traditional, non-instrumental variable methods for mediation analysis experience …
Multivariable Mendelian randomization and mediation
E Sanderson - Cold Spring Harbor perspectives …, 2021 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is the use of genetic variants associated with an exposure to
estimate the causal effect of that exposure on an outcome. Mediation analysis is the method …
estimate the causal effect of that exposure on an outcome. Mediation analysis is the method …