Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct
subcompartments that differ in their biophysical properties and composition. A large number …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Glycoscience assembles all the scientific disciplines involved in studying various molecules
and macromolecules containing carbohydrates and complex glycans. Such an ensemble …

The field of lipidomics has been significantly advanced by mass spectrometric analysis. The
distinction and quantitation of the unsaturated lipid isomers, however, remain a long …

The delivery of therapeutic compounds to target tissues is a central challenge in treating
disease. Externally controlled drug release systems hold potential to selectively enhance …

The functionality of cellular membranes relies on the molecular order imparted by lipids. In
eukaryotes, sterols such as cholesterol modulate membrane order, yet they are not typically …

296a Monday, February 27, 2012 counterparts remains unknown, especially of lipids such
as sphingolipids that, when unlabeled, enter ''raft''domains in model systems, termed …

Sperm plasma membrane lipids are essential for the function and integrity of mammalian
spermatozoa. Various lipid types are involved in each key step within the fertilization …

Lipid rafts, sites of signal transduction, are enriched in glycosphingolipids (GSLs).
Gangliosides, a class of GSLs found in greatest concentration in the grey matter of the brain …

Combined experimental and computational studies of lipid membranes and liposomes, with
the aim to attain mechanistic understanding, result in a synergy that makes possible the …