Rac1 signaling: from intestinal homeostasis to colorectal cancer metastasis
L Kotelevets, E Chastre - Cancers, 2020 - mdpi.com
The small GTPase Rac1 has been implicated in a variety of dynamic cell biological
processes, including cell proliferation, cell survival, cell-cell contacts, epithelial …
processes, including cell proliferation, cell survival, cell-cell contacts, epithelial …
Unwinding chromatin at the right places: how BAF is targeted to specific genomic locations during development
ABSTRACT The BAF (SWI/SNF) chromatin remodeling complex plays a crucial role in
modulating spatiotemporal gene expression during mammalian development. Although its …
modulating spatiotemporal gene expression during mammalian development. Although its …
Akirin2 is critical for inducing inflammatory genes by bridging IκB‐ζ and the SWI/SNF complex
Transcription of inflammatory genes in innate immune cells is coordinately regulated by
transcription factors, including NF‐κB, and chromatin modifiers. However, it remains unclear …
transcription factors, including NF‐κB, and chromatin modifiers. However, it remains unclear …
Distinct transcriptional regulatory modules underlie STAT3's cell type-independent and cell type-specific functions
Transcription factors (TFs) regulate gene expression by binding to short DNA sequence
motifs, yet their binding specificities alone cannot explain how certain TFs drive a diversity of …
motifs, yet their binding specificities alone cannot explain how certain TFs drive a diversity of …
Unkempt is negatively regulated by mTOR and uncouples neuronal differentiation from growth control
A Avet-Rochex, N Carvajal, CP Christoforou… - PLoS …, 2014 - journals.plos.org
Neuronal differentiation is exquisitely controlled both spatially and temporally during
nervous system development. Defects in the spatiotemporal control of neurogenesis cause …
nervous system development. Defects in the spatiotemporal control of neurogenesis cause …
Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of mcp1 protein*: hdac3 mediates allergic skin inflammation
Background: The role of HDAC3 in allergic skin inflammation remains unknown. Results:
HDAC3 interacts with FcϵRI and regulates expression of MCP1 through Sp1 and c-Jun to …
HDAC3 interacts with FcϵRI and regulates expression of MCP1 through Sp1 and c-Jun to …
The role of RING finger proteins in chromatin remodeling and biological functions
Mammalian DNA duplexes are highly condensed with different components, including
histones, enabling chromatin formation. Chromatin remodeling is involved in multiple …
histones, enabling chromatin formation. Chromatin remodeling is involved in multiple …
Decoding the ubiquitin language: Orchestrating transcription initiation and gene expression through chromatin remodelers and histones
Eukaryotic transcription is a finely orchestrated process and it is controlled by transcription
factors as well as epigenetic regulators. Transcription factors and epigenetic regulators …
factors as well as epigenetic regulators. Transcription factors and epigenetic regulators …
Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome
Genetic analysis in Drosophila melanogaster has been widely used to identify a system of
genes that control cell growth in response to insulin and nutrients. Many of these genes …
genes that control cell growth in response to insulin and nutrients. Many of these genes …
Identification of key genes for hypertrophic cardiomyopathy using integrated network analysis of differential lncRNA and gene expression
J Cao, L Yuan - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Objective Hypertrophic cardiomyopathy (HCM) is a complex heterogeneous heart disease.
Recent reports found that long non-coding RNAs (lncRNAs) play an important role in the …
Recent reports found that long non-coding RNAs (lncRNAs) play an important role in the …