Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …

The causative agent of human tuberculosis (TB), M ycobacterium tuberculosis, is an obligate
pathogen that evolved to exclusively persist in human populations. For M. tuberculosis to …

The Photographic Regional Atlas of Bone Disease is intended to serve the needs of a
diverse audience including paleopathologists, physical anthropologists and other …

Microbial archaeology is flourishing in the era of high-throughput sequencing, revealing the
agents behind devastating historical plagues, identifying the cryptic movements of …

The molecular clock and its phylogenetic applications to genomic data have changed how
we study and understand one of the major human pathogens, Mycobacterium tuberculosis …

Background Although tuberculosis accounts for the highest mortality from a bacterial
infection on a global scale, questions persist regarding its origin. One hypothesis based on …

Molecular and phylogeographic studies have led to the definition within the Mycobacterium
tuberculosis complex (MTBC) of a number of geotypes and ecotypes showing a preferential …

Abstract The Mycobacterium tuberculosis Complex (MTBC) consists of a clonal group of
several mycobacterial lineages pathogenic to a range of different mammalian hosts. In this …

The use of ancient DNA in paleopathological studies of tuberculosis has largely been
restricted to confirmation of disease identifications made by skeletal analysis; few attempts at …

There is growing consensus that we have entered the Anthropocene, a geologic epoch
characterized by human domination of the ecosystems of the Earth. With the future …