Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …

Although weight gain is a serious but variable adverse effect of antipsychotics that has
genetic underpinnings, a comprehensive meta-analysis of pharmacogenetics of …

Until menopause, women have a lower propensity to develop metabolic diseases than men,
suggestive of a protective role for sex hormones. Although a functional synergy between …

Agouti-related-peptide (AgRP) neurons—interoceptive neurons in the arcuate nucleus of the
hypothalamus (ARC)—are both necessary and sufficient for driving feeding behavior. To …

The hypothalamus is an evolutionarily conserved brain structure that regulates an
organism's basic functions, such as homeostasis and reproduction. Several hypothalamic …

With the increasing prevalence of energy metabolism disorders such as diabetes,
cardiovascular disease, obesity, and anorexia, the regulation of feeding has become the …

Background The mechanisms by which genetic variants, such as single nucleotide
polymorphisms (SNPs), identified in genome-wide association studies act to influence body …

Abstract The pro-opiomelanocortin (POMC)-expressing neurons of the hypothalamic arcuate
nucleus (ARC) are involved in the control of food intake and metabolic processes. It is …

Melanocortins are peptide hormones critical for the regulation of stress response, energy
homeostasis, inflammation, and skin pigmentation. Their functions are mediated by five G …

Obesity is one of the major pandemics of the 21st century. Due to its multifactorial etiology,
its treatment requires several actions, including dietary intervention and physical exercise …