Discovery, mechanisms of action and combination therapy of artemisinin
Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …
especially in Africa. Throughout history, antimalarial medicines have been one of the most …
Antimalarial drugs–what is in use and what is in the pipeline
M Schlitzer - Archiv der Pharmazie: An International Journal …, 2008 - Wiley Online Library
Malaria continues to be a potentially fatal threat to almost half of the world's population. In
light of this threat, the armory to fight this disease is rather limited. Resistance against the …
light of this threat, the armory to fight this disease is rather limited. Resistance against the …
Evaluation of the anti-malarial activity of crude extract and solvent fractions of the leaves of Olea europaea (Oleaceae) in mice
Background Drug resistance poses a challenge to malaria control measures. This calls for
discovery & development of new chemotherapeutic agents. This study therefore was …
discovery & development of new chemotherapeutic agents. This study therefore was …
A novel artemisinin–quinine hybrid with potent antimalarial activity
JJ Walsh, D Coughlan, N Heneghan, C Gaynor… - Bioorganic & medicinal …, 2007 - Elsevier
Artemisinin was reduced to dihydroartemisinin and coupled to a carboxylic acid derivative of
quinine via an ester linkage. This novel hybrid molecule had potent activity against the 3D7 …
quinine via an ester linkage. This novel hybrid molecule had potent activity against the 3D7 …
In Vitro Activities of Piperaquine, Lumefantrine, and Dihydroartemisinin in Kenyan Plasmodium falciparum Isolates and Polymorphisms in pfcrt and pfmdr1
L Mwai, SM Kiara, A Abdirahman, L Pole… - Antimicrobial agents …, 2009 - Am Soc Microbiol
We have analyzed the in vitro chemosensitivity profiles of 115 Kenyan isolates for
chloroquine (CQ), piperaquine, lumefantrine (LM), and dihydroartemisinin in association …
chloroquine (CQ), piperaquine, lumefantrine (LM), and dihydroartemisinin in association …
Understanding the pharmacokinetics of Coartem®
A Djimdé, G Lefèvre - Malaria journal, 2009 - Springer
Artemether and lumefantrine (AL), the active constituents of Coartem® exhibit
complementary pharmacokinetic profiles. Artemether is absorbed quickly; peak …
complementary pharmacokinetic profiles. Artemether is absorbed quickly; peak …
Drug repositioning in the treatment of malaria and TB
The emergence and spread of drug resistance in the malaria parasite Plasmodium
falciparum as well as multi-and extremely drug-resistant forms of Mycobacterium …
falciparum as well as multi-and extremely drug-resistant forms of Mycobacterium …
Pharmacopeial quality of artemether–lumefantrine anti-malarial agents in Uganda
Background Substandard anti-malarial agents pose a significant challenge to effective
malaria control and elimination efforts especially in sub-Saharan Africa. The quality of anti …
malaria control and elimination efforts especially in sub-Saharan Africa. The quality of anti …
Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults
Objectives Co-administration of artemether/lumefantrine with antiretroviral therapy has
potential for pharmacokinetic drug interactions. We investigated drug–drug interactions …
potential for pharmacokinetic drug interactions. We investigated drug–drug interactions …
In vitro selection of Plasmodium falciparum drug-resistant parasite lines
A Nzila, L Mwai - Journal of antimicrobial chemotherapy, 2010 - academic.oup.com
The in vitro selection of antimicrobial resistance in important pathogens can provide critical
information on the genetic basis of drug resistance, and such information can be used to …
information on the genetic basis of drug resistance, and such information can be used to …