Ion mobility spectrometry is an analytical technique known for more than 100 years, which
entails separating ions in the gas phase based on their size, shape, and charge. While ion …

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human
Diseases | Chemical Reviews Recently Viewedclose modal ACS ACS Publications C&EN CAS …

MYC is a master regulator of stem cell state, embryogenesis, tissue homeostasis, and aging.
As in health, in disease MYC figures prominently. Decades of biological research have …

Intrinsically disordered proteins (IDPs) play crucial roles in cellular processes and hold
promise as drug targets. However, the dynamic nature of IDPs remains poorly understood …

Cancer comprises a heterogeneous disease, characterized by diverse features such as
constitutive expression of oncogenes and/or downregulation of tumor suppressor genes …

Abstract The c-Myc (Myc) oncoprotein is among the most attractive of cancer targets given
that it is de-regulated in the majority of tumors and that its inhibition profoundly affects their …

Increased understanding of intrinsically disordered proteins (IDPs) and protein regions has
revolutionized our view of the relationship between protein structure and function. Data now …

The Myc oncoprotein is a key contributor to the development of many human cancers. As
such, understanding its molecular activities and biological functions has been a field of …

Intrinsically disordered proteins (IDPs) are associated with various diseases and have been
proposed as promising drug targets. However, conventional structure-based approaches …

Drugs that target intracellular signalling pathways have markedly improved progression-free
survival of patients with cancers who were previously regarded as untreatable. However, the …