The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

For decades, immunologists have studied the role of circulating immune cells in host
protection, with a more recent appreciation of immune cells resident within the tissue …

Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract
infections that produce a wide spectrum of clinical disease severity in humans. The novel …

Influenza virus affects the respiratory tract by direct viral infection or by damage from the
immune system response. In humans, the respiratory epithelium is the only site where the …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
coronavirus disease 2019 (COVID-19). Understanding of the fundamental processes …

The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal
role in tissue homeostasis and repair. While the ECM was long thought to mostly have …

Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …

Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC)
limits drug penetration into the tumor and is associated with poor prognosis. Here, we …

The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three
decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs …

Severe respiratory infections can result in acute respiratory distress syndrome (ARDS).
There are no effective pharmacological therapies that have been shown to improve …