Diagnosis of multiple sclerosis: progress and challenges

WJ Brownlee, TA Hardy, F Fazekas, DH Miller - The Lancet, 2017 - thelancet.com
The diagnosis of multiple sclerosis is based on neurological symptoms and signs, alongside
evidence of dissemination of CNS lesions in space and time. MRI is often sufficient to …

The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis …

P Sati, J Oh, RT Constable, N Evangelou… - Nature Reviews …, 2016 - nature.com
Over the past few years, MRI has become an indispensable tool for diagnosing multiple
sclerosis (MS). However, the current MRI criteria for MS diagnosis have imperfect sensitivity …

The cerebrospinal fluid in multiple sclerosis

F Deisenhammer, H Zetterberg, B Fitzner… - Frontiers in …, 2019 - frontiersin.org
Investigation of cerebrospinal fluid (CSF) in the diagnostic work-up in suspected multiple
sclerosis (MS) patients has regained attention in the latest version of the diagnostic criteria …

MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis—clinical implementation in the diagnostic process

À Rovira, MP Wattjes, M Tintoré, C Tur… - Nature Reviews …, 2015 - nature.com
The clinical use of MRI in patients with multiple sclerosis (MS) has advanced markedly over
the past few years. Technical improvements and continuously emerging data from clinical …

The contemporary spectrum of multiple sclerosis misdiagnosis: a multicenter study

AJ Solomon, DN Bourdette, AH Cross, A Applebee… - Neurology, 2016 - neurology.org
Objective: To characterize patients misdiagnosed with multiple sclerosis (MS). Methods:
Neurologists at 4 academic MS centers submitted data on patients determined to have been …

Association between pathological and MRI findings in multiple sclerosis

M Filippi, W Brück, D Chard, F Fazekas… - The Lancet …, 2019 - thelancet.com
Pathological evaluation is the gold standard for identifying processes related to multiple
sclerosis that explain disease manifestations, and for guiding the development of new …

Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies

P Maggi, M Absinta, M Grammatico, L Vuolo… - Annals of …, 2018 - Wiley Online Library
Objectives In multiple sclerosis (MS), magnetic resonance imaging (MRI) is a sensitive tool
for detecting white matter lesions, but its diagnostic specificity is still suboptimal; ambiguous …

Misdiagnosis of multiple sclerosis: Impact of the 2017 McDonald criteria on clinical practice

AJ Solomon, RT Naismith, AH Cross - Neurology, 2019 - neurology.org
Misdiagnosis of multiple sclerosis (MS)(the incorrect assignment of a diagnosis of MS)
remains a problem in contemporary clinical practice. Studies indicate that misdiagnosed …

Cerebrospinal fluid oligoclonal bands in multiple sclerosis and clinically isolated syndromes: a meta-analysis of prevalence, prognosis and effect of latitude

R Dobson, S Ramagopalan, A Davis… - Journal of Neurology …, 2013 - jnnp.bmj.com
Background Oligoclonal bands (OCBs) unique to the cerebrospinal fluid are used in the
diagnosis of multiple sclerosis (MS). The precise prevalence of OCBs in MS and clinically …

White matter diseases with radiologic-pathologic correlation

N Sarbu, RY Shih, RV Jones, I Horkayne-Szakaly… - Radiographics, 2016 - pubs.rsna.org
White matter diseases include a wide spectrum of disorders that have in common
impairment of normal myelination, either by secondary destruction of previously myelinated …