Genetic polymorphism varies among species and within genomes, and has important
implications for the evolution and conservation of species. The determinants of this variation …

Speciation, the evolution of reproductive isolation among populations, is continuous,
complex, and involves multiple, interacting barriers. Until it is complete, the effects of this …

Recent work has hinted at the linkage disequilibrium (LD)-dependent architecture of human
complex traits, where SNPs with low levels of LD (LLD) have larger per-SNP heritability …

We develop a Bayesian mixed linear model that simultaneously estimates single-nucleotide
polymorphism (SNP)-based heritability, polygenicity (proportion of SNPs with nonzero …

The spread of modern humans across the globe has led to genetic adaptations to diverse
local environments. Recent developments in genomic technologies, statistical analyses, and …

Speciation is a continuous process during which genetic changes gradually accumulate in
the genomes of diverging species. Recent studies have documented highly heterogeneous …

Individuals from different populations vary considerably in their susceptibility to immune-
related diseases. To understand how genetic variation and natural selection contribute to …

A major challenge in genetics is to identify genetic variants driving natural phenotypic
variation. However, current methods of genetic map** have limited resolution. To address …

Adaptation from standing genetic variation or recurrent de novo mutation in large
populations should commonly generate soft rather than hard selective sweeps. In contrast to …

The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
emphasized the vulnerability of human populations to novel viral pressures, despite the vast …