Recent Progress in Functionalization of the Pyridine Ring through C− S Bond Formation under Transition Metal Catalyst Free Conditions
OA Tikhanova, DI Bugaenko… - Advanced Synthesis & …, 2024 - Wiley Online Library
Pyridines and quinolines substituted with sulfur‐containing functional groups are widely
used as drugs, drug candidates, organic materials, N, S‐ligands and others. Traditional …
used as drugs, drug candidates, organic materials, N, S‐ligands and others. Traditional …
1-Benzhydryl-piperazine: Isolation, structure determination, and in silico studies for a novel potential narcotic agent detected in sports supplements
Adulteration of sports supplements poses significant health risks, necessitating stringent
regulatory oversight. This study investigates deceptive practices by manufacturers, including …
regulatory oversight. This study investigates deceptive practices by manufacturers, including …
Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors
B Kuhn, M Ritter, B Hornsperger, C Bell… - Journal of Medicinal …, 2024 - ACS Publications
Monoacylglycerol lipase (MAGL) is a key enzyme involved in the metabolism of the
endogenous signaling ligand 2-arachidonoylglycerol, a neuroprotective endocannabinoid …
endogenous signaling ligand 2-arachidonoylglycerol, a neuroprotective endocannabinoid …
Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs
H Zhao, Y Liu, N Cai, X Liao, L Tang… - Drug Design …, 2024 - Taylor & Francis
Over the past decade, the idea of targeting the endocannabinoid system to treat anxiety
disorders has received increasing attention. Previous studies focused more on develo** …
disorders has received increasing attention. Previous studies focused more on develo** …
[HTML][HTML] Benzopyran hydrazones with dual PPARα/γ or PPARα/δ agonism and an anti-inflammatory effect on human THP-1 macrophages
A García, L Vila, I Duplan, MA Schiel, RD Enriz… - European Journal of …, 2024 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) play a major role in regulating
inflammatory processes, and dual or pan-PPAR agonists with PPARγ partial activation have …
inflammatory processes, and dual or pan-PPAR agonists with PPARγ partial activation have …
Formal synthesis of ferruginol methyl ether via an acid-catalysed intramolecular Diels–Alder cycloaddition
MM Alonso, LS Andrés, JG Marrero - Tetrahedron Letters, 2024 - Elsevier
Aromatic abietane diterpenoids, known for their wide range of biological and pharmaceutical
activities, have attracted considerable interest from synthetic and medicinal chemists …
activities, have attracted considerable interest from synthetic and medicinal chemists …