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Exercise-induced myokines and their effect on prostate cancer
Exercise is recognized by clinicians in the field of clinical oncology for its potential role in
reducing the risk of certain cancers and in reducing the risk of disease recurrence and …
reducing the risk of certain cancers and in reducing the risk of disease recurrence and …
Matricellular proteins: extracellular modulators of cell function
P Bornstein, EH Sage - Current opinion in cell biology, 2002 - Elsevier
The term 'matricellular'has been applied to a group of extracellular proteins that do not
contribute directly to the formation of structural elements in vertebrates but serve to modulate …
contribute directly to the formation of structural elements in vertebrates but serve to modulate …
A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise
W Aoi, Y Naito, T Takagi, Y Tanimura, Y Takanami… - Gut, 2013 - gut.bmj.com
Objective Several epidemiological studies have shown that regular exercise can prevent the
onset of colon cancer, although the underlying mechanism is unclear. Myokines are …
onset of colon cancer, although the underlying mechanism is unclear. Myokines are …
Ovarian cancer microenvironment: implications for cancer dissemination and chemoresistance acquisition
Ovarian adenocarcinoma is characterized by a late detection, dissemination of cancer cells
into the whole peritoneum, and the frequent acquisition of chemoresistance. If these …
into the whole peritoneum, and the frequent acquisition of chemoresistance. If these …
SPARC in cancer biology: its role in cancer progression and potential for therapy
The ability to effectively target a tumor to achieve complete regression and cure is the
ultimate goal that drives our need to better understand tumor biology. Recently, SPARC has …
ultimate goal that drives our need to better understand tumor biology. Recently, SPARC has …
The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host
Tumor growth is essentially the result of an evolving cross-talk between malignant and
surrounding stromal cells (fibroblasts, endothelial cells and inflammatory cells). This …
surrounding stromal cells (fibroblasts, endothelial cells and inflammatory cells). This …
SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor–stromal interactions
N Sato, N Fukushima, N Maehara, H Matsubayashi… - Oncogene, 2003 - nature.com
Deregulated expression of SPARC/osteonectin, a secreted glycoprotein with multiple
biological functions, has been associated with the progression of various cancers. Using …
biological functions, has been associated with the progression of various cancers. Using …
Exercise in advanced prostate cancer elevates myokine levels and suppresses in-vitro cell growth
Background Altering the systemic milieu through exercise has been proposed as a potential
mechanism underlying exercise-driven tumour suppression. It is not yet known whether men …
mechanism underlying exercise-driven tumour suppression. It is not yet known whether men …
Network-based survival analysis reveals subnetwork signatures for predicting outcomes of ovarian cancer treatment
Cox regression is commonly used to predict the outcome by the time to an event of interest
and in addition, identify relevant features for survival analysis in cancer genomics. Due to …
and in addition, identify relevant features for survival analysis in cancer genomics. Due to …
Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene map** to the commonly deleted region in 5q− syndrome patients
A Pellagatti, M Jädersten, AM Forsblom… - Proceedings of the …, 2007 - pnas.org
Myelodysplastic syndromes (MDSs) are a group of hematopoietic stem cell disorders
characterized by ineffective hematopoiesis and peripheral blood cytopenias. Lenalidomide …
characterized by ineffective hematopoiesis and peripheral blood cytopenias. Lenalidomide …