Understanding the molecular mechanisms of statin pleiotropic effects
Statins represent the cornerstone of pharmacotherapy for the prevention of atherosclerotic
cardiovascular disease. These medications not only reduce low-density lipoprotein …
cardiovascular disease. These medications not only reduce low-density lipoprotein …
Mechanisms of foam cell formation in atherosclerosis
Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is
maintained by specialized cells, such as macrophages. Macrophages express a variety of …
maintained by specialized cells, such as macrophages. Macrophages express a variety of …
Macrophage‐mediated cholesterol handling in atherosclerosis
Formation of foam cells is a hallmark at the initial stages of atherosclerosis. Monocytes
attracted by pro‐inflammatory stimuli attach to the inflamed vascular endothelium and …
attracted by pro‐inflammatory stimuli attach to the inflamed vascular endothelium and …
[HTML][HTML] Antioxidative activity of high-density lipoprotein (HDL): Mechanistic insights into potential clinical benefit
F Brites, M Martin, I Guillas, A Kontush - BBA clinical, 2017 - Elsevier
Uptake of low-density lipoprotein (LDL) particles by macrophages represents a key step in
the development of atherosclerotic plaques, leading to the foam cell formation. Chemical …
the development of atherosclerotic plaques, leading to the foam cell formation. Chemical …
Role of endothelial dysfunction in atherosclerosis
As the major regulator of vascular homeostasis, the endothelium exerts a number of
vasoprotective effects, such as vasodilation, suppression of smooth muscle cell growth, and …
vasoprotective effects, such as vasodilation, suppression of smooth muscle cell growth, and …
Beneficial cardiovascular pleiotropic effects of statins
J Davignon - Circulation, 2004 - ahajournals.org
Pleiotropic effects of a drug are actions other than those for which the agent was specifically
developed. These effects may be related or unrelated to the primary mechanism of action of …
developed. These effects may be related or unrelated to the primary mechanism of action of …
Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy
Cardiovascular disease is the biggest killer globally and the principal contributing factor to
the pathology is atherosclerosis; a chronic, inflammatory disorder characterized by lipid and …
the pathology is atherosclerosis; a chronic, inflammatory disorder characterized by lipid and …
Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL …
M Aviram, M Rosenblat, D Gaitini, S Nitecki, A Hoffman… - Clinical nutrition, 2004 - Elsevier
Dietary supplementation with polyphenolic antioxidants to animals was shown to be
associated with inhibition of LDL oxidation and macrophage foam cell formation, and …
associated with inhibition of LDL oxidation and macrophage foam cell formation, and …
Immunobiology of atherosclerosis: a complex net of interactions
B Herrero-Fernandez, R Gomez-Bris… - International Journal of …, 2019 - mdpi.com
Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the
principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory …
principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory …
Paraoxonases 1, 2, and 3, oxidative stress, and macrophage foam cell formation during atherosclerosis development
M Aviram, M Rosenblat - Free Radical Biology and Medicine, 2004 - Elsevier
Paraoxonases PON1 and PON3, which are both associated in serum with HDL, protect the
serum lipids from oxidation, probably as a result of their ability to hydrolyze specific oxidized …
serum lipids from oxidation, probably as a result of their ability to hydrolyze specific oxidized …