The widespread applications of benzophenone (BP) photochemistry in biological chemistry,
bioorganic chemistry, and material science have been prominent in both academic and …

The development and application of chemical technologies enabling direct analysis of
enzyme activity in living systems has undergone explosive growth in recent years. Activity …

Photoaffinity labeling (PAL) is a powerful technique in chemical biology and chemical
proteomics, and has been successfully demonstrated on a variety of non-covalent molecular …

This article presents several covalent inhibitors, including examples of successful drugs, as
well as highly selective, irreversible inhibitors of emerging therapeutic targets, such as fatty …

Protein kinases (PKs) play an important role in the development and progression of cancer
by regulating cell growth, survival, invasion, metastasis, and angiogenesis. Dasatinib (BMS …

Although several recent reviews dealt with transition metal catalyzed N-arylation of amines
(all classes), to date no specific review covering the N-arylation of amidines and guanidines …

Among several anions, iodide (I−) ions play a crucial role in human biological activities. In
it's molecular form (I2), iodine is utilized for several industrial applications such as syntheses …

Photoaffinity labeling has a longstanding history as a powerful biochemical technique.
However, photoaffinity labeling has significantly evolved over the past decade principally …

Highlights•Drug discovery is time-consuming and expensive in part due to unexpected side-
effects.•Identification of cellular targets of drug candidates is important to address this …

Activity-based protein profiling (ABPP) is a chemical proteomic technique that enables the
interrogation of protein activity directly within complex proteomes. Given the dominant role of …