Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Frailty, a consequence of the interaction of the aging process and certain chronic diseases,
compromises functional outcomes in the elderly and substantially increases their risk for …

Many physiological changes occur with aging. These changes often, directly or indirectly,
result in a deterioration of the quality of life and even in a shortening of life expectancy …

Autophagy is a lysosomal degradation process and protective housekee** mechanism to
eliminate damaged organelles, long-lived misfolded proteins and invading pathogens …

Autophagy is a major protein turnover pathway by which cellular components are delivered
into the lysosomes for degradation and recycling. This intracellular process is able to …

Mechanisms of protein homeostasis are crucial for overseeing the clearance of misfolded
and toxic proteins over the lifetime of an organism, thereby ensuring the health of neurons …

Accumulation of dysfunctional and damaged cellular proteins and organelles occurs during
aging, resulting in a disruption of cellular homeostasis and progressive degeneration and …

Sarcopenia is distinct from normal muscle atrophy in that it is closely related to a shift in the
muscle fiber type. Deficiency of the anabolic action of androgen on skeletal muscles is …

Sarcopenia is an age-related geriatric syndrome that is characterized by a progressive loss
of muscle mass, strength and function. Chronic heart failure (CHF), the final stage of various …

The rapid increase in both the lifespan and proportion of older adults is accompanied by the
unprecedented rise in age-associated chronic diseases, including sarcopenia and obesity …