Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …
Controlling and enhancing CRISPR systems
Many bacterial and archaeal organisms use clustered regularly interspaced short
palindromic repeats–CRISPR associated (CRISPR–Cas) systems to defend themselves …
palindromic repeats–CRISPR associated (CRISPR–Cas) systems to defend themselves …
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
CRISPR-Cas systems provide microbes with adaptive immunity to infectious nucleic acids
and are widely employed as genome editing tools. These tools use RNA-guided Cas …
and are widely employed as genome editing tools. These tools use RNA-guided Cas …
Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing
CRISPR-Cas13 proteins are RNA-guided RNA nucleases that defend against incoming
RNA and DNA phages by binding to complementary target phage transcripts followed by …
RNA and DNA phages by binding to complementary target phage transcripts followed by …
Anti-CRISPR: discovery, mechanism and function
CRISPR–Cas adaptive immune systems are widespread among bacteria and archaea.
Recent studies have shown that these systems have minimal long-term evolutionary effects …
Recent studies have shown that these systems have minimal long-term evolutionary effects …
Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies
Clustered, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have …
associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have …
Spatiotemporal control of CRISPR/Cas9 gene editing
The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein
9 (CRISPR/Cas9) gene editing technology, as a revolutionary breakthrough in genetic …
9 (CRISPR/Cas9) gene editing technology, as a revolutionary breakthrough in genetic …
[HTML][HTML] CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy
Y Xu, Z Li - Computational and structural biotechnology journal, 2020 - Elsevier
Genome editing is the modification of genomic DNA at a specific target site in a wide variety
of cell types and organisms, including insertion, deletion and replacement of DNA, resulting …
of cell types and organisms, including insertion, deletion and replacement of DNA, resulting …
A compact, high-accuracy Cas9 with a dinucleotide PAM for in vivo genome editing
CRISPR-Cas9 genome editing has transformed biotechnology and therapeutics. However,
in vivo applications of some Cas9s are hindered by large size (limiting delivery by adeno …
in vivo applications of some Cas9s are hindered by large size (limiting delivery by adeno …
Inhibitors of bacterial immune systems: discovery, mechanisms and applications
To contend with the diversity and ubiquity of bacteriophages and other mobile genetic
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …