The quantum nature of electrons and nuclei is manifested in countless biological events
including the rearrangements of electrons in biochemical reactions, electron and proton …

The brain is a singular organ of unique biological complexity that serves as the command
center for cognitive and motor function. As such, this specialized system also possesses a …

Copper is too redox active to exist in an unbound form in the cell without causing oxidative
damage: an upper limit of 10-18 M for the free concentration of Cu (II) in unstressed cells has …

Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

Although a functional role in copper binding has been suggested for the prion protein,
evidence for binding at affinities characteristic of authentic metal-binding proteins has been …

Amyloidogenesis is a characteristic feature of the 40 or so known protein deposition
diseases, and accumulating evidence strongly suggests that self-association of misfolded …

A conformational change of the prion protein is responsible for a class of neurodegenerative
diseases called the transmissible spongiform encephalopathies that include mad cow …

Recent evidence suggests that the prion protein (PrP) is a copper binding protein. The N-
terminal region of human PrP contains four sequential copies of the highly conserved …

To test for a role for the cellular prion protein (PrP c) in cell death, we used a PrP c‐binding
peptide. Retinal explants from neonatal rats or mice were kept in vitro for 24 h, and …

In the 20 years, since the introduction of electrospray mass spectrometry (ESI‐MS), the use
of this technique in various fields of inorganic, organometallic, and analytical chemistry has …