Nitric oxide signalling in cardiovascular health and disease
Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …
Non-coding genetic variants in human disease
Genetic variants, including single-nucleotide variants (SNVs) and copy number variants
(CNVs), in the non-coding regions of the human genome can play an important role in …
(CNVs), in the non-coding regions of the human genome can play an important role in …
An international, multicentered, evidence-based reappraisal of genes reported to cause congenital long QT syndrome
A Adler, V Novelli, AS Amin, E Abiusi, M Care… - Circulation, 2020 - Am Heart Assoc
Background: Long QT syndrome (LQTS) is the first described and most common inherited
arrhythmia. Over the last 25 years, multiple genes have been reported to cause this …
arrhythmia. Over the last 25 years, multiple genes have been reported to cause this …
Epidemiology and genetics of sudden cardiac death
R Deo, CM Albert - Circulation, 2012 - Am Heart Assoc
Sudden cardiac death (SCD) generally refers to an unexpected death from a cardiovascular
cause in a person with or without preexisting heart disease. The specificity of this definition …
cause in a person with or without preexisting heart disease. The specificity of this definition …
Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies
Background During the past 5 years, high-throughput technologies have been successfully
used by epidemiology studies, but almost all have focused on sequence variation through …
used by epidemiology studies, but almost all have focused on sequence variation through …
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
CR Bezzina, J Barc, Y Mizusawa, CA Remme… - Nature …, 2013 - nature.com
Brugada syndrome is a rare cardiac arrhythmia disorder, causally related to SCN5A
mutations in around 20% of cases,,. Through a genome-wide association study of 312 …
mutations in around 20% of cases,,. Through a genome-wide association study of 312 …
The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies
Research into cardiac autonomic control has received great interest in the past 20 years,
and we are now at a critical juncture with regard to the clinical translation of the experimental …
and we are now at a critical juncture with regard to the clinical translation of the experimental …
Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop
Despite the significant decline in coronary artery disease (CAD) mortality in the second half
of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 …
of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 …
Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits
The obesity epidemic is responsible for a substantial economic burden in developed
countries and is a major risk factor for type 2 diabetes and cardiovascular disease. The …
countries and is a major risk factor for type 2 diabetes and cardiovascular disease. The …
Association of mitochondrial DNA copy number with cardiovascular disease
Importance Mitochondrial dysfunction is a core component of the aging process and may
play a key role in atherosclerotic cardiovascular disease. Mitochondrial DNA copy number …
play a key role in atherosclerotic cardiovascular disease. Mitochondrial DNA copy number …