Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Atherosclerosis and its attendant clinical complications, such as myocardial infarction,
stroke, and peripheral artery disease, are the leading cause of morbidity and mortality in …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

Background and Purpose—The purpose of this study was to identify significant
morphological and hemodynamic parameters that discriminate intracranial aneurysm …

Background and Purpose—Arterial bifurcation apices are common sites for cerebral
aneurysms, raising the possibility that the unique hemodynamic conditions associated with …

It is well accepted that atherosclerosis occurs in a site-specific manner especially at branch
points where disturbed blood flow (d-flow) predisposes to the development of plaques …

Objective—Vascular endothelial cells (ECs) are subjected to shear stress and cytokine
stimulation. We studied the interplay between shear stress and cytokine in modulating the …

Atherosclerosis preferentially develops at branches and curvatures of the arterial tree, where
blood flow is disturbed from a laminar pattern, and wall shear stress is non-uniform and has …

Abnormal vascular remodeling mediated by inflammatory cells has been identified as a key
pathologic component of various vascular diseases, including abdominal aortic aneurysms …

BACKGROUND: Recent evidence suggests a link between the magnitude and distribution of
hemodynamic factors and the formation and rupture of intracranial aneurysms. However …