Chemokines are chemo tactic cyto kines that control the migratory patterns and positioning
of all immune cells. Although chemokines were initially appreciated as important mediators …

Regulatory T (Treg) cells that express the transcription factor forkhead box protein P3
(FOXP3) are naturally present in the immune system and have roles in the maintenance of …

Human induced pluripotent stem cells (iPSC) hold promise for modeling diseases in
individual human genetic backgrounds and thus for develo** precision medicine. Here …

Abstract Foxp3+ regulatory T (Treg) cells expressing the interleukin (IL)-33 receptor ST2
mediate tissue repair in response to IL-33. Whether Treg cells also respond to the alarmin IL …

Memory CD4+ T helper type 2 (Th2) cells drive allergic asthma, yet the mechanisms
whereby tissue-resident memory Th2 (Th2 Trm) cells and circulating memory Th2 cells …

Background Intracerebral hemorrhage (ICH), a devastating subtype of stroke, is associated
with high mortality and morbidity. Neuroinflammation is an important factor leading to ICH …

Objectives Randomised-controlled trials have recently proven the efficacy of the interleukin
(IL)-6 receptor antagonist tocilizumab (TCZ) in giant cell arteritis (GCA). However, the …

Inflammatory bone resorption is a hallmark of periodontitis, and Tregs and Th2 cells are
independently associated with disease progression attenuation. In this study, we employed …

Eosinophilic disorders encompass a large spectrum of heterogeneous diseases sharing the
presence of elevated numbers of eosinophils in blood and/or tissues. Among these …

During viral infection, inflammation and recovery are tightly controlled by competing
proinflammatory and regulatory immune pathways. Respiratory syncytial virus (RSV) is the …